Early trials suggest it may be effective not just on its own, but especially when combined with GLP-1 therapies, creating a powerful one-two punch against overeating and excess weight
As with other GLP-1 drugs, people taking PF3944 lost substantially more weight than the placebo group
Anxiety-like behavior In rats, supplementation with HFD (G0-P21 [137] and P20-84 [134], a high-fat-high-sugar diet (P21-91) [138], palatable diet (P21-P60) [139] or highly palatable food diet (P28-56 [133] and P22-59 [136] and P20-84 [135]) reversed the POS - induced anxiety-like behavior as measured in the OFT at M4-7 [137] and P54-59 [133, 136], in the EPM between W10-12 [134, 138], P60-P67 [139] and at P54-59 [133] and in the LDB at W10-12 [134] and at P34-84 in females [135]
[DOI] [PubMed] [Google Scholar] Littlejohn EA, Monrad SU
Supports investigation into gene expression related to tissue repair